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KMID : 1134819990280010205
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 1 p.205 ~ p.211
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Effects of Houttyunia cordata Ethanol Extracts on Serum Lipids and Antioxidant Enzymes in Rats Fed High Fat Diet
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Chung Cha-Kwon
Ham Seung-Shi
Lee Sang-Young
Oh Deog-Hwan
Choi Soo-Yong
Kang Il-Jun
Nam Sang-Myung
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Abstract
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Effects of Houttuynia cordata ethanol extracts on lipid metabolism and antioxidant enzymes in Sprague Dawley male rats were investigated. High fat used in the diet mixture included 10% of lard, 1% of cholesterol and 0.25% of sodium cholate. Total serum cholesterol contents of the rats fed Houttuynia cordata extracts were decreased compared to the control. On the other hand, HDL-cholesterol contents were increased along with the decrease of athrogenic index. When high fat diet was fed, total serum cholesterol contents were significantly increased(p＜0.01) with the athrogenic index increase of four times of the control. With the administration of Houttuynia cordata extract HDL-cholesterol was increased by 53% in the high fat diet group. Antioxidant enzymes including GST and catalase activities were increased comparing the control. On the otherhand, the extracts lowered phospholipid(p＜0.01), GOT, GPT, Cu,Zn-SOD and alkaline phosphatase enzyme activities in the serum which are related to the liver functions. Therefore, the above results suggest that Houttuynia cordata ethanol extracts can help to maintain normal liver functions and help to protect from peroxidative damages caused by excess dietary fat intake.
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KEYWORD
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Houttuynia cordata, serum cholesterol, antioxidant enzymes, high fat
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